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GABAA receptors are well preserved in the hippocampus of aged mice.
SIGNIFICANCE STATEMENT This work highlights the effect of receptor coactivation and signal integration in a developmental setting.
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We reveal that column formation is initiated by three core neurons that establish distinct concentric domains within a column.
The human connectome has become the very frequent subject of study of.
TrkB and CaSR colocalize within late endosomes, cotraffic and coactivate GSK3, which serves as a shared signaling node for both receptors.
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In this study, we report that receptor signaling does not follow a linear path but changes dependent on developmental stage and coreceptors involved.
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Individual striatal neurons preserved normal baseline activity and network interactions following the disinhibition, maintaining the normal encoding of behavioral primitives and forming a sparse link between the LFP spikes and single neuron activity.
In particular, we study how.
Neural circuit development involves the coordinated growth and guidance of axons.
These behavioral and neuronal results highlight the direct interplay on multiple timescales between different striatal territories during normal and pathological conditions.
Plasticity after stroke is a complex phenomenon initiated by the functional.
We argue that disturbances of such configurations in the brain may.
Column formation is initiated by three core neurons, R8, R7, and Mi1, which establish distinct concentric domains within a column.
Temporal connection signatures of human brain networks after stroke.
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GABAAR α1, α2, α3, α5, β3 and 2 subunit expression level differences found between the young (6 months) and old (21 months) age groups in any of the hippocampal regions examined.
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SIGNIFICANCE STATEMENT The nucleus accumbens (NAc) is a key part of the striatal limbic territory.
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Further, we found no significant correlation between the microstructural measures and mean RT.
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Recordings from primary sensory trigeminal ganglion neurons show that these neurons exhibit responses consistent with those that would be predicted from direct touch.
These findings suggest a population code for airflow speed and direction and open new avenues for studying vibrissotactile regions of the brain.
Finally, we showed that these temporal.
Disinhibition of this classically limbic territory leads to profound motor changes resembling hyperactivity and attention deficit.
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Aging is the main risk factor for Alzheimer's disease and other neurodegenerative disorders characterized by established remodeling of the hippocampal GABAergic system.
This study investigates the whiskers' mechanical response to airflow and the associated neural response.
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SIGNIFICANCE STATEMENT The rodent vibrissal (whisker) system has been studied for decades in the context of direct tactile sensation, but recent work has indicated that rats also use whiskers to help localize airflow.
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Organization of Neurons within a Columnar Unit in the Drosophila Medulla.
Surprisingly, the direction of the whisker's vibration changes as a function of airflow speed: vibrations transition from parallel to perpendicular with respect to the airflow as airspeed increases.
Although this study used only female rats, all results are expected to generalize to male rats.
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These cues are sensed by receptors at the surface that trigger intracellular signaling events modulating the cytoskeleton.
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Moreover, the presence of.
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These tools need to address the high.
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To study this setting, we consider a population rate.
SIGNIFICANCE STATEMENT How does our brain structure contribute to our speed to react?
The medulla, the largest ganglion of the Drosophila melanogaster visual center, provides a unique opportunity to reveal the mechanisms of 3D organization of the columns.
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This Week in The Journal.
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We explore carefully the dynamics.
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Decades of research have investigated the rat vibrissal (whisker) system in the context of direct touch and tactile stimulation, but recent work has shown that rats also use their whiskers to help detect and localize airflow.
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We consider the stroboscopic map for.
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Columnar structure is a basic unit of the brain, but the mechanism underlying its development remains largely unknown.
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However, the local connection mechanisms.
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Until now, structural connectomics was only rarely able identifying such causes.
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We also propose the presence of mutual interactions among the three layers during formation of the 3D structures of the medulla columns.
This paper suggests a statistical framework for describing the relations.
During this process, axons encounter many different cues, but how these cues are integrated and translated into growth is poorly understood.
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The theory of communication through coherence (CTC) proposes that brain.
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MRI processing workflow, and need to find structural causes.
Neural Signatures of Motor Skill in the Resting Brain.
In the present work, we study the frequent neighbor sets of.
Then, using longitudinal functional.
During embryonic development, neurites grow toward their targets guided by cues in the extracellular environment.
To test our hypothesis, we adopted a statistical approach based.
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